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~Unleashing the functions of biomaterials with amoeba hydrogel~
Alliance
Enzymatic Synthesis Process of API
Gel Coat Biomaterials, Inc. provides research and development services to improve the manufacturing process of Active Pharmaceutical ingredients (API）
The biomanufacturing process is applied broadly for API manufacturing. Since enzymes and high-quality raw materials for API manufacturing are expensive, it is important to improve the long-term stability and thermal stability of enzymes to increase the productivity of biomanufacturing. Chemical reactions using enzymes and other biological substances are known to produce chemicals with low energy consumption and high production yield, so they are attracting attention as a new production method for reducing carbon dioxide emissions. Amoeba Hydrogel of Gel Coat Biomaterials, Inc. protects enzymes to increase their stability. With conventional methods, stabilizing individual enzymes requires time-consuming research and development, such as genetic recombination or genetic modification. Amoeba Hydrogel improves the stability of a wide variety of enzymes by changing its shape flexibly to fit the biomaterial.
Our Amoeba Hydrogel is a physical cross-linked gel, not chemical cross-linked gel, so the substrate can penetrate the hydrogel, and enzyme activity is not disturbed. Enzymes can maintain and improve the activity of enzyme chemical reactions at higher temperatures and even in organic solvents. It can be used for compounds and biomolecules that are insoluble in water, improving API production efficiency.
Biopharmaceutical
We provide research and development services to improve the stability of biopharmaceuticals against degrading enzymes.
Biopharmaceuticals and drug delivery systems (DDS) are affected by proteinase in the body. Our Amoeba Hydrogel can improves the anti-proteinase stability of biopharmaceuticals. In addition, our hydrogel is biocompatible and is expected to enhance drug efficacy without compromising drug safety.
Bio-Synthesis and Decomposition
(Acceleration of Plastic Decomposition)
We provide research and development services to improve the stability of enzymes for bio-synthesis and bio-decomposition.
For example, plastic-decomposing enzymes are expected to solve the problem of plastic waste. Protecting the enzyme with our Amoeba Hydrogel improves the enzyme’s organic solvent stability and high-temperature stability. Amoeba Hydrogel can accelerate the decomposition of plastic waste by supporting the enzymatic reaction in organic solvents and at high temperatures.
New Therapeutics with Bio Power Generator
We are developing a bio power generator using enzymes by taking advantage of the long-term stabilization and activity enhancement of enzymes by Amoeba Hydrogel. We have already succeeded in a demonstration experiment of long-term power generation from enzymes and glucose existing in the body.
When our bio power generator is mounted in an implantable device, it is protected by hydrogel so that it can withstand sterilization treatment and can generate electricity continuously in vivo without being charged beforehand. We are developing this technology to realize new treatment methods, such as deep brain stimulation, and photogenetic therapy for malignant tumors, which have been difficult to treat with drugs.
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